Cancer is still an incurable disease, caused by the accumulation of somatic mutations. The recent technologies in high-throughput experimentation and next-generation sequencing have generated a huge amount of data, providing a unique opportunity to computationally challenge this deadly disease. This project will focus on the study of long noncoding RNAs in cancer. Particularly, we will use glioblastoma, an aggressive type of brain tumor as a proof-of-concept example to identify noncoding RNAs that might play important role in cancer progression.