Functional roles of Arfpr1 in regulating export of cargo proteins out of the trans Golgi network
Project Description
Arfrp1 is an Arf family protein that is located at the trans Golgi network (TGN). Evidence suggests that Arfrp1 functions in tethering vesicles to the TGN. Interestingly, we have evidence suggests that Arfrp1 can also function to mediate sorting of cargo proteins at the TGN. In this project, we will perform biochemical and cell biological approaches to investigate the functional roles of Arfrp1 in TGN export process.
Supervisor
GUO, Yusong
Quota
1
Course type
UROP3200
Applicant's Roles
The UG student will work together with a PG student to perform protein interaction studies to analyze whether Arfrp1 regulates the interaction between adaptor protein complex-1 (AP-1) and cargo clients.
Applicant's Learning Objectives
To study whether Arfrp1 promote AP-1 to interact with its cargo , Vangl2
Complexity of the project
Moderate