Investigating the dynamics of single DNA molecules using magnetic tweezers
Project Description
The dynamics of DNA molecules is important because of the importance of DNA dynamics in cellular processes, e.g. replication of and transcription of DNA molecules. Magnetic tweezers experiments have probed the dynamics of DNA molecules. Using magnetic tweezers, we investigate the dynamics of single DNA molecules containing G-quadruplex secondary structures since quadruplex formation plays a role in many cellular functions including replication and transcription.
Supervisor
PARK, Hyo Keun
Quota
2
Course type
UROP1000
UROP1100
UROP2100
UROP3100
UROP3200
UROP4100
Applicant's Roles
1. To perform magnetic tweezers experiments.
2. To interpret experimental data.
3. To find how the dynamics of G-quadruplex change under different conformations.
2. To interpret experimental data.
3. To find how the dynamics of G-quadruplex change under different conformations.
Applicant's Learning Objectives
1. Learn how to perform magnetic tweezers experiments.
2. Study how the dynamics of G-quadruplex change under different conformations.
2. Study how the dynamics of G-quadruplex change under different conformations.
Complexity of the project
Challenging