Peroxisomes are organelles for the processing of specific fatty acids. Genetic mutations that disrupt peroxisomal function cause varying degrees of liver dysfunction, developmental delay, and neurological defects that impair one's ability to move, see and hear. In this project, mutations that mimic those found in human patients will be introduced into C. elegans. The transgenic animals could potentially be used for genetic and drug screens to identify therapeutic strategies for treating peroxisomal disorders.